NIPT: Non-Invasive Prenatal Test
What is Non-Invasive Prenatal Testing (NIPT)?
Non-Invasive Prenatal Testing (NIPT) is an advanced prenatal screening test that analyses small fragments of cell-free DNA (cfDNA) circulating in the mother’s bloodstream during pregnancy.
Most of the pregnancy-related cfDNA comes from the placenta and usually reflects the baby’s genetic makeup.
NIPT screens for the likelihood of certain chromosomal conditions, including:
- Down syndrome (Trisomy 21) – caused by an extra copy of chromosome 21.
- Edwards syndrome (Trisomy 18) – caused by an extra copy of chromosome 18.
- Patau syndrome (Trisomy 13) – caused by an extra copy of chromosome 13.
Depending on the test and screening package selected, additional screening may be available for sex chromosome conditions, certain rare chromosomal abnormalities and selected microdeletion syndromes.
NIPT is a screening test rather than a diagnostic test. Although highly accurate for the three common trisomies, it cannot confirm or completely rule out a chromosomal condition.
Which NIPT Tests Are Available at ReproScan?
We offer two NIPT screening options (PRENASCAN and PANORAMA), allowing expectant parents to choose the test most suitable for their pregnancy.
PRENASCAN – Non-Invasive Prenatal Screening
PRENASCAN is an advanced prenatal screening test that analyses cell-free DNA found in the mother’s blood.
It can be performed from 10 weeks of pregnancy and uses whole-genome screening technology to assess the likelihood of a range of chromosomal abnormalities.
PRENASCAN offers screening for:
- Down syndrome (Trisomy 21)
- Edwards syndrome (Trisomy 18)
- Patau syndrome (Trisomy 13)
- Sex chromosome abnormalities
PRENASCAN can also provide information about the baby’s sex if requested (no extra cost).
The test is suitable for many singleton and twin pregnancies, although some screening options may be limited.
Panorama™ – Non-Invasive Prenatal Screening
Panorama™, developed by Natera, is an advanced NIPT screening test that uses unique single nucleotide polymorphism (SNP)-based technology to analyse DNA from the pregnancy.
Panorama can be performed from 9 weeks of pregnancy, subject to the testing laboratory’s requirements.
Panorama screens for:
- Down syndrome (Trisomy 21)
- Edwards syndrome (Trisomy 18)
- Patau syndrome (Trisomy 13)
- Certain sex chromosome abnormalities
- Triploidy, where applicable
Additional Screening Options (Available Upon Request)
Patients wishing to include additional screening with their Panorama NIPT test can choose from the following options:
- DiGeorge Syndrome (22q11.2 deletion) – Additional fee €100 (payable at the clinic)
- Extended Microdeletion Panel – Additional fee €200 (payable at the clinic) includes:
- 22q11.2 deletion syndrome (DiGeorge syndrome)
- 1p36 deletion syndrome
- Angelman syndrome
- Prader-Willi syndrome
- Cri-du-chat syndrome
Panorama can also provide information about the baby’s sex if requested. (no extra cost)
When Can I Have an NIPT Test?
NIPT can be performed early in pregnancy.
- PRENASCAN: From 10 weeks of pregnancy.
- Panorama: From 9 weeks of pregnancy.
If you are unsure how many weeks pregnant you are, we recommend booking an NIPT Test with Early Pregnancy Scan.
An ultrasound scan can help confirm your gestational age, check the pregnancy and establish whether you are expecting one baby or twins.
If your pregnancy is too early for the chosen NIPT test, our team will advise you when to return for your blood test.
How Is The Test Performed?
Before your blood sample is taken, a sonographer will explain the test and answer any questions you may have. You will then be asked to sign a consent form.
If you have not had an early pregnancy scan, an ultrasound may be performed to confirm your gestational age. If an ultrasound scan is required, an additional fee of €125 will apply, payable at the clinic.
How Long Will It Take To Get The Results?
Results are generally available within the following timeframes after your blood sample reaches the laboratory:
- Panorama: Within 10 working days.
- PRENASCAN: Within 9 working days.
Occasionally, results may take longer, or the laboratory may request a repeat blood sample if there is insufficient DNA for reliable analysis.
What Happens If My NIPT Result Is High Risk?
If your PRENASCAN or Panorama result indicates a high likelihood of a chromosomal condition, our team will discuss the result with you and explain the recommended next steps.
We can provide a referral for specialist fetal medicine assessment, where further ultrasound examination, genetic counselling or diagnostic testing may be discussed.
A high-risk NIPT result should be confirmed with diagnostic testing before making important decisions about the pregnancy.
How Much Does NIPT Testing Cost?
ReproScan offers PRENASCAN and Panorama NIPT screening, with the option to include an early pregnancy ultrasound scan.
The cost will depend on the test and screening package selected.
For current prices and availability, please visit our online booking page.
How Do I book?
If you’d like to book your NIPT Test, please use our online booking system for your preferred clinic: